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3ajo

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Current revision (14:29, 1 November 2023) (edit) (undo)
 
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[[Image:3ajo.png|left|200px]]
 
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==Crystal structure of wild-type human ferritin H chain==
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The line below this paragraph, containing "STRUCTURE_3ajo", creates the "Structure Box" on the page.
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<StructureSection load='3ajo' size='340' side='right'caption='[[3ajo]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ajo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AJO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3ajo| PDB=3ajo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ajo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajo OCA], [https://pdbe.org/3ajo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ajo RCSB], [https://www.ebi.ac.uk/pdbsum/3ajo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ajo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aj/3ajo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ajo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ferritins are ubiquitous iron storage proteins. Recently, we identified a novel metal-binding site, transit site, in the crystal structure of phytoferritin. To elucidate the function of the transit site in ferritin from other species, we prepared transit-site-deficient mutants of human H ferritin, E140A and E140Q, and their iron oxidation kinetics was analyzed. The initial velocities of iron oxidization were reduced in the variants, especially in E140Q. The crystal structure of E140Q showed that the side chain of the mutated Gln140 was fixed by a hydrogen bond, whereas that of native Glu140 was flexible. These results suggest that the conserved transit site also has a function to assist with the metal ion sequestration to the ferroxidase site in ferritins from vertebrates.
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===Crystal structure of wild-type human ferritin H chain===
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The universal mechanism for iron translocation to the ferroxidase site in ferritin, which is mediated by the well conserved transit site.,Masuda T, Goto F, Yoshihara T, Mikami B Biochem Biophys Res Commun. 2010 Aug 10. PMID:20705053<ref>PMID:20705053</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20705053}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ajo" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20705053 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20705053}}
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==About this Structure==
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[[3ajo]] is a 1 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJO OCA].
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==See Also==
==See Also==
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*[[Ferritin]]
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*[[Ferritin 3D structures|Ferritin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20705053</ref><references group="xtra"/>
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__TOC__
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[[Category: Ferroxidase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Masuda, T.]]
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[[Category: Large Structures]]
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[[Category: Mikami, B.]]
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[[Category: Masuda T]]
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[[Category: 4-helix bundle]]
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[[Category: Mikami B]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of wild-type human ferritin H chain

PDB ID 3ajo

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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