3bya

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[[Image:3bya.png|left|200px]]
 
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==Structure of a Calmodulin Complex==
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The line below this paragraph, containing "STRUCTURE_3bya", creates the "Structure Box" on the page.
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<StructureSection load='3bya' size='340' side='right'caption='[[3bya]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3bya| PDB=3bya | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bya OCA], [https://pdbe.org/3bya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bya RCSB], [https://www.ebi.ac.uk/pdbsum/3bya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bya ProSAT]</span></td></tr>
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</table>
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===Structure of a Calmodulin Complex===
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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[[3bya]] is a 2 chain structure of [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYA OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3bya_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bya ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Calmodulin]]
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Birrane, G.]]
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[[Category: Large Structures]]
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[[Category: Ladias, J A.A.]]
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[[Category: Birrane G]]
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[[Category: Soni, A.]]
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[[Category: Ladias JAA]]
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[[Category: Acetylation]]
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[[Category: Soni A]]
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[[Category: Alternative splicing]]
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[[Category: Calcium channel]]
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[[Category: Calmodulin]]
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[[Category: Cell junction]]
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[[Category: Central nervous system]]
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[[Category: Ef hand motif]]
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[[Category: Glutamate]]
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[[Category: Glycoprotein]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Magnesium]]
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[[Category: Membrane]]
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[[Category: Metal binding protein]]
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[[Category: Methylation]]
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[[Category: N-methyl-d-aspartate receptor]]
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[[Category: Neuronal channel]]
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[[Category: Nr1]]
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[[Category: Phosphoprotein]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: Synapse]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Ubl conjugation]]
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Current revision

Structure of a Calmodulin Complex

PDB ID 3bya

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Proteopedia Page Contributors and Editors (what is this?)

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