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1z5s

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[[Image:1z5s.png|left|200px]]
 
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==Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2==
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The line below this paragraph, containing "STRUCTURE_1z5s", creates the "Structure Box" on the page.
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<StructureSection load='1z5s' size='340' side='right'caption='[[1z5s]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z5s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z5S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z5s OCA], [https://pdbe.org/1z5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z5s RCSB], [https://www.ebi.ac.uk/pdbsum/1z5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z5s ProSAT]</span></td></tr>
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{{STRUCTURE_1z5s| PDB=1z5s | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2===
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[https://www.uniprot.org/uniprot/UBC9_HUMAN UBC9_HUMAN] Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.<ref>PMID:8668529</ref> <ref>PMID:11451954</ref> <ref>PMID:15809060</ref> <ref>PMID:19744555</ref> <ref>PMID:19638400</ref> <ref>PMID:17466333</ref> <ref>PMID:20077568</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15931224 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/1z5s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15931224}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z5s ConSurf].
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[[1z5s]] is a 4 chain structure of [[Nucleoporin]] and [[SUMO]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z5S OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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*[[SUMO]]
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:15931224</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Large Structures]]
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[[Category: Lima, C D.]]
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[[Category: Lima CD]]
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[[Category: Reverter, D.]]
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[[Category: Reverter D]]
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[[Category: E3]]
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[[Category: Ligase]]
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[[Category: Nuclear pore complex]]
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[[Category: Sumo]]
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[[Category: Ubc9]]
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Current revision

Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2

PDB ID 1z5s

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