3ewe

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[[Image:3ewe.png|left|200px]]
 
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==Crystal Structure of the Nup85/Seh1 Complex==
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The line below this paragraph, containing "STRUCTURE_3ewe", creates the "Structure Box" on the page.
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<StructureSection load='3ewe' size='340' side='right'caption='[[3ewe]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ewe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EWE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ewe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ewe OCA], [https://pdbe.org/3ewe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ewe RCSB], [https://www.ebi.ac.uk/pdbsum/3ewe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ewe ProSAT]</span></td></tr>
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{{STRUCTURE_3ewe| PDB=3ewe | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUP85_YEAST NUP85_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP85 is involved in nuclear poly(A)+ RNA and pre-ribosome export, in GSP1 nuclear import, in NPC assembly and distribution, as well as in nuclear envelope organization.<ref>PMID:8816998</ref> <ref>PMID:9774696</ref> <ref>PMID:11071906</ref> <ref>PMID:12543930</ref> <ref>PMID:11823431</ref> <ref>PMID:12730220</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/3ewe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ewe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nuclear pore complexes (NPCs) facilitate nucleocytoplasmic transport. These massive assemblies comprise an eight-fold symmetric scaffold of architectural proteins and central-channel phenylalanine-glycine-repeat proteins forming the transport barrier. We determined the Nup85*Seh1 structure, a module in the heptameric Nup84 complex, at 3.5 A resolution. Structural, biochemical, and genetic analyses position the Nup84 complex in two peripheral NPC rings. We establish a conserved tripartite element, the ancestral coatomer element ACE1, that reoccurs in several nucleoporins and vesicle coat proteins, providing structural evidence of coevolution from a common ancestor. We identify interactions that define the organization of the Nup84 complex based on comparison with vesicle coats and confirmed the sites by mutagenesis. We propose the NPC scaffold, like vesicle coats, is composed of polygons with vertices and edges forming a membrane-proximal lattice providing docking sites for additional nucleoporins.
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===Crystal Structure of the Nup85/Seh1 Complex===
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Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats.,Brohawn SG, Leksa NC, Spear ED, Rajashankar KR, Schwartz TU Science. 2008 Oct 30. PMID:18974315<ref>PMID:18974315</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3ewe" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18974315 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18974315}}
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==About this Structure==
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[[3ewe]] is a 4 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EWE OCA].
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==See Also==
==See Also==
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*[[Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18974315</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Brohawn, S G.]]
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[[Category: Brohawn SG]]
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[[Category: Leksa, N C.]]
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[[Category: Leksa NC]]
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[[Category: Rajashankar, K R.]]
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[[Category: Rajashankar KR]]
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[[Category: Schwartz, T U.]]
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[[Category: Schwartz TU]]
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[[Category: Cell membrane]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Mrna transport]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleoporin]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Structural protein]]
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[[Category: Translocation]]
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[[Category: Transport]]
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[[Category: Wd repeat]]
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Current revision

Crystal Structure of the Nup85/Seh1 Complex

PDB ID 3ewe

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Proteopedia Page Contributors and Editors (what is this?)

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