1l5j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1l5j" [edit=sysop:move=sysop])
Current revision (07:29, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1l5j.png|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF E. COLI ACONITASE B.==
-
The line below this paragraph, containing "STRUCTURE_1l5j", creates the "Structure Box" on the page.
+
<StructureSection load='1l5j' size='340' side='right'caption='[[1l5j]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1l5j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L5J FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=TRA:ACONITATE+ION'>TRA</scene></td></tr>
-
{{STRUCTURE_1l5j| PDB=1l5j | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l5j OCA], [https://pdbe.org/1l5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l5j RCSB], [https://www.ebi.ac.uk/pdbsum/1l5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l5j ProSAT]</span></td></tr>
-
 
+
</table>
-
===CRYSTAL STRUCTURE OF E. COLI ACONITASE B.===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/ACNB_ECOLI ACNB_ECOLI] Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Also catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. During oxidative stress inactive AcnB apo-enzyme without iron sulfur clusters binds the acnB mRNA 3' UTRs (untranslated regions), stabilizes acnB mRNA and increases AcnB synthesis, thus mediating a post-transcriptional positive autoregulatory switch. AcnB also decreases the stability of the sodA transcript.<ref>PMID:10585860</ref> <ref>PMID:10589714</ref> <ref>PMID:11932448</ref> <ref>PMID:12473114</ref> <ref>PMID:15882410</ref> <ref>PMID:8000525</ref> <ref>PMID:8932712</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_11992126}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11992126 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l5/1l5j_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_11992126}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[1l5j]] is a 2 chain structure of [[Aconitase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L5J OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l5j ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Aconitase]]
+
*[[Aconitase 3D structures|Aconitase 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:11992126</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Aconitate hydratase]]
+
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Artymiuk, P J.]]
+
[[Category: Large Structures]]
-
[[Category: Barynin, V V.]]
+
[[Category: Artymiuk PJ]]
-
[[Category: Green, J.]]
+
[[Category: Barynin VV]]
-
[[Category: Guest, J R.]]
+
[[Category: Green J]]
-
[[Category: Sedelnikova, S E.]]
+
[[Category: Guest JR]]
-
[[Category: Stillman, T J.]]
+
[[Category: Sedelnikova SE]]
-
[[Category: Tang, Y.]]
+
[[Category: Stillman TJ]]
-
[[Category: Williams, C H.]]
+
[[Category: Tang Y]]
-
[[Category: Citric acid cycle]]
+
[[Category: Williams CH]]
-
[[Category: Heat-like domain]]
+
-
[[Category: Lyase]]
+
-
[[Category: Molecular recognition]]
+
-
[[Category: Rna binding]]
+

Current revision

CRYSTAL STRUCTURE OF E. COLI ACONITASE B.

PDB ID 1l5j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1l5j"
Personal tools