1jqy

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[[Image:1jqy.png|left|200px]]
 
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==HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010==
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The line below this paragraph, containing "STRUCTURE_1jqy", creates the "Structure Box" on the page.
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<StructureSection load='1jqy' size='340' side='right'caption='[[1jqy]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jqy]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A32:(3-NITRO-5-(3-MORPHOLIN-4-YL-PROPYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE'>A32</scene></td></tr>
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{{STRUCTURE_1jqy| PDB=1jqy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqy OCA], [https://pdbe.org/1jqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqy RCSB], [https://www.ebi.ac.uk/pdbsum/1jqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The action of cholera toxin and E. coli heat-labile enterotoxin can be inhibited by blocking their binding to the cell-surface receptor GM1. We have used anchor-based design to create 15 receptor binding inhibitors that contain the previously characterized inhibitor MNPG as a substructure. In ELISA assays, all 15 compounds exhibited increased potency relative to MNPG. Binding affinities for two compounds, each containing a morpholine ring linked to MNPG via a hydrophobic tail, were characterized by pulsed ultrafiltration (PUF) and isothermal titration calorimetry (ITC). Crystal structures for these compounds bound to toxin B pentamer revealed a conserved binding mode for the MNPG moiety, with multiple binding modes adopted by the attached morpholine derivatives. The observed binding interactions can be exploited in the design of improved toxin binding inhibitors.
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===HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010===
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Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.,Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E Chem Biol. 2002 Feb;9(2):215-24. PMID:11880036<ref>PMID:11880036</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11880036}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1jqy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11880036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11880036}}
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==About this Structure==
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[[1jqy]] is a 15 chain structure of [[Cholera toxin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQY OCA].
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==See Also==
==See Also==
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*[[Cholera toxin]]
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*[[Cholera toxin 3D structures|Cholera toxin 3D structures]]
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*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:11880036</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Hol, W G.J.]]
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[[Category: Large Structures]]
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[[Category: Merritt, E A.]]
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[[Category: Hol WGJ]]
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[[Category: B-pentamer]]
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[[Category: Merritt EA]]
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[[Category: Enterotoxin]]
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[[Category: Ligand]]
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[[Category: Receptor]]
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Current revision

HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010

PDB ID 1jqy

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