2kvp

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[[Image:2kvp.png|left|200px]]
 
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==Solution Structure of the R10 Domain of Talin==
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The line below this paragraph, containing "STRUCTURE_2kvp", creates the "Structure Box" on the page.
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<StructureSection load='2kvp' size='340' side='right'caption='[[2kvp]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kvp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvp OCA], [https://pdbe.org/2kvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvp RCSB], [https://www.ebi.ac.uk/pdbsum/2kvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvp ProSAT]</span></td></tr>
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{{STRUCTURE_2kvp| PDB=2kvp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kv/2kvp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kvp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. Its rod region consists of a series of helical bundles. Here we show that residues 1815-1973 form a 5-helix bundle, with a topology unique to talin which is optimally suited for formation of a long rod such as talin. This is much more stable than the 4-helix (1843-1973) domain described earlier and as a result its vinculin binding sequence is inaccessible to vinculin at room temperature, with implications for the overall mechanism of the talin-vinculin interaction.
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===NMR structure of the talin VBS3 domain, 1815-1973===
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The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.,Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC FEBS Lett. 2010 Jun 3;584(11):2237-41. Epub 2010 Apr 20. PMID:20399778<ref>PMID:20399778</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20399778}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kvp" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20399778 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20399778}}
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==About this Structure==
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[[2kvp]] is a 1 chain structure of [[Talin]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVP OCA].
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==See Also==
==See Also==
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*[[Talin]]
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*[[Talin 3D structures|Talin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20399778</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Barsukov, I L.]]
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[[Category: Barsukov IL]]
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[[Category: Bate, N.]]
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[[Category: Bate N]]
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[[Category: Critchley, D R.]]
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[[Category: Critchley DR]]
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[[Category: Gingras, A R.]]
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[[Category: Gingras AR]]
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[[Category: Goult, B T.]]
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[[Category: Goult BT]]
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[[Category: Roberts, G C.]]
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[[Category: Roberts GC]]
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[[Category: Acetylation]]
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[[Category: Cell membrane]]
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[[Category: Cell projection]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Helical bundle]]
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[[Category: Membrane]]
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[[Category: Phosphoprotein]]
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[[Category: Structural protein]]
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[[Category: Talin]]
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[[Category: Vb]]
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[[Category: Vinculin]]
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Current revision

Solution Structure of the R10 Domain of Talin

PDB ID 2kvp

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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