3ihy

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[[Image:3ihy.png|left|200px]]
 
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==Human PIK3C3 crystal structure==
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The line below this paragraph, containing "STRUCTURE_3ihy", creates the "Structure Box" on the page.
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<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
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{{STRUCTURE_3ihy| PDB=3ihy | SCENE= }}
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</table>
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== Function ==
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===Human PIK3C3 crystal structure===
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[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[3ihy]] is a 5 chain structure of [[Phosphoinositide 3-Kinases]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphoinositide 3-Kinases]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van Den.]]
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[[Category: Berglund H]]
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[[Category: Berglund, H.]]
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[[Category: Bountra C]]
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[[Category: Bountra, C.]]
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[[Category: Collins R]]
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[[Category: Collins, R.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Flodin S]]
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[[Category: Flodin, S.]]
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[[Category: Flores A]]
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[[Category: Flores, A.]]
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[[Category: Graslund S]]
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[[Category: Graslund, S.]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M.]]
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[[Category: Johansson A]]
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[[Category: Johansson, A.]]
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[[Category: Johansson I]]
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[[Category: Johansson, I.]]
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[[Category: Karlberg T]]
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[[Category: Karlberg,T.]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T.]]
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[[Category: Kotzsch A]]
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[[Category: Kotzsch, A.]]
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[[Category: Kragh Nielsen T]]
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[[Category: Moche, M.]]
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[[Category: Moche M]]
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[[Category: Nielsen, T Kragh.]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P.]]
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[[Category: Nyman T]]
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[[Category: Nyman, T.]]
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[[Category: Persson C]]
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[[Category: Persson, C.]]
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[[Category: Roos AK]]
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[[Category: Roos, A K.]]
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[[Category: Sagemark J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Schueler H]]
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[[Category: Sagemark, J.]]
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[[Category: Schutz P]]
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[[Category: Schueler, H.]]
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[[Category: Siponen MI]]
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[[Category: Schutz, P.]]
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[[Category: Thorsell AG]]
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[[Category: Siponen, M I.]]
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[[Category: Tresaugues L]]
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[[Category: Thorsell, A G.]]
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[[Category: Van Den Berg S]]
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[[Category: Tresaugues, L.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Welin M]]
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[[Category: Welin, M.]]
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[[Category: Wisniewska M]]
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[[Category: Wisniewska, M.]]
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[[Category: Alpha/beta protein]]
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[[Category: Atp-binding]]
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[[Category: Kinase]]
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[[Category: Manganese]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Sgc stockholm]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Human PIK3C3 crystal structure

PDB ID 3ihy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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