1joh

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[[Image:1joh.png|left|200px]]
 
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==THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE==
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The line below this paragraph, containing "STRUCTURE_1joh", creates the "Structure Box" on the page.
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<StructureSection load='1joh' size='340' side='right'caption='[[1joh]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1joh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Emericellopsis Emericellopsis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000161:Antiamoebin+1'>PRD_000161</scene></td></tr>
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{{STRUCTURE_1joh| PDB=1joh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1joh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1joh OCA], [https://pdbe.org/1joh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1joh RCSB], [https://www.ebi.ac.uk/pdbsum/1joh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1joh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BACKGROUND: Antiamoebin is a member of the peptaibol family of polypeptides and has a unique antibiotic activity: it acts as an antiamoebic agent, but does not effectively haemolyze erythrocytes even though it does exhibit membrane-modifying activity. RESULTS: The structure of antiamoebin I has been determined by X-ray crystallography at 1.4 A resolution. The molecule forms a helical structure, which, as a result of the presence of a number of proline and hydroxyproline residues, has a deep bend in the middle. Circular dichroism spectroscopy, single-channel conductance studies and fluorescence diffusion studies suggest a mode of ion transport that is entirely different from that of the other two members of the peptaibol family (alamethicin and zervamicin) whose structures and functions have been examined in detail. CONCLUSIONS: The structure of the polypeptide has been determined and a functional model for its mode of action in membranes is presented. Although under some conditions antiamoebin may form ion channels, unlike the closely related alamethicin and zervamicin polypeptides, its major membrane-modifying activity appears to be as an ion carrier.
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===THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE===
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The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide.,Snook CF, Woolley GA, Oliva G, Pattabhi V, Wood SF, Blundell TL, Wallace BA Structure. 1998 Jun 15;6(6):783-92. PMID:9655831<ref>PMID:9655831</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1joh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9655831 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9655831}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1joh]] is a 2 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Emericellopsis Emericellopsis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOH OCA].
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==See Also==
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*[[Ion channels]]
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==Reference==
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<ref group="xtra">PMID:9655831</ref><references group="xtra"/>
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[[Category: Emericellopsis]]
[[Category: Emericellopsis]]
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[[Category: Snook, C F.]]
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[[Category: Large Structures]]
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[[Category: Wallace, B A.]]
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[[Category: Snook CF]]
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[[Category: Antiamoebin]]
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[[Category: Wallace BA]]
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[[Category: Peptaibol]]
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[[Category: Peptide antibiotic]]
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Current revision

THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE

PDB ID 1joh

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