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1tg4

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[[Image:1tg4.png|left|200px]]
 
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==Design of specific inhibitors of groupII phospholipase A2(PLA2): Crystal structure of the complex formed between russells viper PLA2 and designed peptide Phe-Leu-Ala-Tyr-Lys at 1.7A resolution==
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The line below this paragraph, containing "STRUCTURE_1tg4", creates the "Structure Box" on the page.
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<StructureSection load='1tg4' size='340' side='right'caption='[[1tg4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_russelii Daboia russelii russelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TG4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1tg4| PDB=1tg4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tg4 OCA], [https://pdbe.org/1tg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tg4 RCSB], [https://www.ebi.ac.uk/pdbsum/1tg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tg4 ProSAT]</span></td></tr>
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</table>
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===Design of specific inhibitors of groupII phospholipase A2(PLA2): Crystal structure of the complex formed between russells viper PLA2 and designed peptide Phe-Leu-Ala-Tyr-Lys at 1.7A resolution===
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== Function ==
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[https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[1tg4]] is a 2 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Daboia_russellii_russellii Daboia russellii russellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TG4 OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tg4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tg4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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[[Category: Daboia russellii russellii]]
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== References ==
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[[Category: Betzel, C.]]
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<references/>
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[[Category: Dey, S.]]
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__TOC__
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[[Category: Ethayathulla, A S.]]
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</StructureSection>
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[[Category: Perbandt, M.]]
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[[Category: Daboia russelii russelii]]
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[[Category: Sharma, S.]]
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[[Category: Large Structures]]
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[[Category: Singh, N.]]
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[[Category: Betzel C]]
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[[Category: Singh, T P.]]
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[[Category: Dey S]]
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[[Category: Somvanshi, R K.]]
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[[Category: Ethayathulla AS]]
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[[Category: Complex]]
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[[Category: Perbandt M]]
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[[Category: Crystal structure]]
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[[Category: Sharma S]]
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[[Category: Flayk]]
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[[Category: Singh N]]
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[[Category: Hydrolase]]
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[[Category: Singh TP]]
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[[Category: Phospholipase a2]]
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[[Category: Somvanshi RK]]
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[[Category: Specific inhibitor]]
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Current revision

Design of specific inhibitors of groupII phospholipase A2(PLA2): Crystal structure of the complex formed between russells viper PLA2 and designed peptide Phe-Leu-Ala-Tyr-Lys at 1.7A resolution

PDB ID 1tg4

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OCA

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