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1t3s

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[[Image:1t3s.png|left|200px]]
 
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==Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core==
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The line below this paragraph, containing "STRUCTURE_1t3s", creates the "Structure Box" on the page.
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<StructureSection load='1t3s' size='340' side='right'caption='[[1t3s]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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{{STRUCTURE_1t3s| PDB=1t3s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3s OCA], [https://pdbe.org/1t3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3s RCSB], [https://www.ebi.ac.uk/pdbsum/1t3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3s ProSAT]</span></td></tr>
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</table>
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===Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core===
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== Function ==
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[https://www.uniprot.org/uniprot/CACB2_RABIT CACB2_RABIT] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15163634}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15163634 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3s_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15163634}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1t3s]] is a 1 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3S OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3s ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels (Part II)]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:15163634</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Campbell, K P.]]
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[[Category: Campbell KP]]
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[[Category: Chen, C C.]]
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[[Category: Chen C-C]]
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[[Category: Hirsch, J A.]]
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[[Category: Hirsch JA]]
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[[Category: Opatowsky, Y.]]
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[[Category: Opatowsky Y]]
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[[Category: Guanylate kinase domain]]
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[[Category: Sh3 domain]]
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[[Category: Transport protein]]
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Current revision

Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core

PDB ID 1t3s

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