2rey
From Proteopedia
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| - | [[Image:2rey.jpg|left|200px]]<br /><applet load="2rey" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2rey, resolution 1.55Å" /> | ||
| - | '''Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)'''<br /> | ||
| - | == | + | ==Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)== |
| - | + | <StructureSection load='2rey' size='340' side='right'caption='[[2rey]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2rey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rey OCA], [https://pdbe.org/2rey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rey RCSB], [https://www.ebi.ac.uk/pdbsum/2rey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rey ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2rey_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rey ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Cooper | + | [[Category: Cooper C]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards AM]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Sundstrom M]] |
| - | + | [[Category: Turnbull A]] | |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Ugochukwu | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Cooper C | Doyle D | Edwards AM | Elkins J | Gileadi C | Gileadi O | Papagrigoriou E | Pike ACW | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
