3jw8

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[[Image:3jw8.png|left|200px]]
 
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==Crystal structure of human mono-glyceride lipase==
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The line below this paragraph, containing "STRUCTURE_3jw8", creates the "Structure Box" on the page.
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<StructureSection load='3jw8' size='340' side='right'caption='[[3jw8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3jw8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JW8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3jw8| PDB=3jw8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jw8 OCA], [https://pdbe.org/3jw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jw8 RCSB], [https://www.ebi.ac.uk/pdbsum/3jw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jw8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jw8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jw8 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Monoglyceride lipase (MGL) is a serine hydrolase that hydrolyses 2-arachidonoylglycerol (2-AG) into arachidonic acid and glycerol. 2-AG is an endogenous ligand of cannabinoid receptors, involved in various physiological processes in the brain. We present here the first crystal structure of human MGL in its apo form and in complex with the covalent inhibitor SAR629. MGL shares the classic fold of the alpha/beta hydrolase family but depicts an unusually large hydrophobic occluded tunnel with a highly flexible lid at its entry and the catalytic triad buried at its end. Structures reveal the configuration of the catalytic triad and the shape and nature of the binding site of 2-AG. The bound structure of SAR629 highlights the key interactions for productive binding with MGL. The shape of the tunnel suggests a high druggability of the protein and provides an attractive template for drug discovery.
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===Crystal structure of human mono-glyceride lipase===
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Structural basis for human monoglyceride lipase inhibition.,Bertrand T, Auge F, Houtmann J, Rak A, Vallee F, Mikol V, Berne PF, Michot N, Cheuret D, Hoornaert C, Mathieu M J Mol Biol. 2010 Feb 26;396(3):663-73. Epub 2009 Dec 3. PMID:19962385<ref>PMID:19962385</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19962385}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3jw8" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19962385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19962385}}
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==About this Structure==
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[[3jw8]] is a 2 chain structure of [[Lipase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JW8 OCA].
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==See Also==
==See Also==
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*[[Lipase]]
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*[[Lipase 3D Structures|Lipase 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19962385</ref><references group="xtra"/>
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__TOC__
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[[Category: Acylglycerol lipase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Auge, F.]]
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[[Category: Large Structures]]
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[[Category: Berne, P F.]]
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[[Category: Auge F]]
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[[Category: Bertrand, T.]]
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[[Category: Berne PF]]
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[[Category: Cheuret, D.]]
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[[Category: Bertrand T]]
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[[Category: Hoornaert, C.]]
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[[Category: Cheuret D]]
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[[Category: Houtmann, J.]]
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[[Category: Hoornaert C]]
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[[Category: Mathieu, M.]]
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[[Category: Houtmann J]]
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[[Category: Michot, N.]]
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[[Category: Mathieu M]]
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[[Category: Mikol, V.]]
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[[Category: Michot N]]
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[[Category: Rak, A.]]
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[[Category: Mikol V]]
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[[Category: Vallee, F.]]
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[[Category: Rak A]]
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[[Category: Alpha-beta hydrolase]]
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[[Category: Vallee F]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of human mono-glyceride lipase

PDB ID 3jw8

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