2if4

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[[Image:2if4.png|left|200px]]
 
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==Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana==
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The line below this paragraph, containing "STRUCTURE_2if4", creates the "Structure Box" on the page.
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<StructureSection load='2if4' size='340' side='right'caption='[[2if4]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2if4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if4 OCA], [https://pdbe.org/2if4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if4 RCSB], [https://www.ebi.ac.uk/pdbsum/2if4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if4 ProSAT]</span></td></tr>
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{{STRUCTURE_2if4| PDB=2if4 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana===
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[https://www.uniprot.org/uniprot/FKB42_ARATH FKB42_ARATH] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway.<ref>PMID:14517332</ref> <ref>PMID:15133126</ref> <ref>PMID:14730066</ref> <ref>PMID:16887800</ref> <ref>PMID:18499676</ref> <ref>PMID:20971896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17045295 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/if/2if4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17045295}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2if4 ConSurf].
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[[2if4]] is a 1 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF4 OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17045295</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Eckhoff, A.]]
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[[Category: Large Structures]]
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[[Category: Granzin, J.]]
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[[Category: Eckhoff A]]
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[[Category: Weiergraeber, O H.]]
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[[Category: Granzin J]]
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[[Category: Alpha]]
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[[Category: Weiergraeber OH]]
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[[Category: Alpha-beta]]
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[[Category: Fkbp-like]]
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[[Category: Signaling protein]]
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[[Category: Tpr-like]]
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Current revision

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana

PDB ID 2if4

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OCA

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