2a5g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:11, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2a5g.png|left|200px]]
 
-
<!--
+
==Cholera toxin A1 subunit bound to ARF6(Q67L)==
-
The line below this paragraph, containing "STRUCTURE_2a5g", creates the "Structure Box" on the page.
+
<StructureSection load='2a5g' size='340' side='right'caption='[[2a5g]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2a5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5G FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_2a5g| PDB=2a5g | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5g OCA], [https://pdbe.org/2a5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5g RCSB], [https://www.ebi.ac.uk/pdbsum/2a5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5g ProSAT]</span></td></tr>
-
 
+
</table>
-
===Cholera toxin A1 subunit bound to ARF6(Q67L)===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/ARF6_HUMAN ARF6_HUMAN] GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension.<ref>PMID:7589240</ref> <ref>PMID:14978216</ref> <ref>PMID:11266366</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16099990}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16099990 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a5g_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_16099990}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[2a5g]] is a 2 chain structure of [[Cholera toxin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5G OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a5g ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Cholera toxin]]
+
*[[Cholera toxin 3D structures|Cholera toxin 3D structures]]
-
 
+
*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:16099990</ref><references group="xtra"/>
+
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
-
[[Category: Hol, W G.J.]]
+
[[Category: Hol WGJ]]
-
[[Category: Holmes, R K.]]
+
[[Category: Holmes RK]]
-
[[Category: Jobling, M G.]]
+
[[Category: Jobling MG]]
-
[[Category: Neal, C J.O.]]
+
[[Category: O'Neal CJ]]
-
[[Category: Protein transport/transferase]]
+

Current revision

Cholera toxin A1 subunit bound to ARF6(Q67L)

PDB ID 2a5g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a5g"
Personal tools