1wlh

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[[Image:1wlh.png|left|200px]]
 
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==Molecular structure of the rod domain of Dictyostelium filamin==
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The line below this paragraph, containing "STRUCTURE_1wlh", creates the "Structure Box" on the page.
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<StructureSection load='1wlh' size='340' side='right'caption='[[1wlh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wlh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WLH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wlh OCA], [https://pdbe.org/1wlh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wlh RCSB], [https://www.ebi.ac.uk/pdbsum/1wlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wlh ProSAT]</span></td></tr>
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{{STRUCTURE_1wlh| PDB=1wlh | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GELA_DICDI GELA_DICDI] F-actin cross-linking protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/1wlh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wlh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
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===Molecular structure of the rod domain of Dictyostelium filamin===
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Molecular structure of the rod domain of dictyostelium filamin.,Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587<ref>PMID:15364587</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15364587}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1wlh" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15364587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15364587}}
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==About this Structure==
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[[1wlh]] is a 2 chain structure of [[Filamin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WLH OCA].
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==See Also==
==See Also==
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*[[Filamin]]
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*[[Filamin 3D structures|Filamin 3D structures]]
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*[[User:Georg Mlynek/workbench|User:Georg Mlynek/workbench]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:15364587</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Holak, T A.]]
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[[Category: Large Structures]]
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[[Category: Huber, R.]]
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[[Category: Holak TA]]
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[[Category: Mueller, R.]]
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[[Category: Huber R]]
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[[Category: Noegel, A A.]]
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[[Category: Mueller R]]
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[[Category: Popowicz, G M.]]
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[[Category: Noegel AA]]
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[[Category: Schleicher, M.]]
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[[Category: Popowicz GM]]
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[[Category: Abp-120]]
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[[Category: Schleicher M]]
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[[Category: Filamin]]
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[[Category: Immunoglobulin fold]]
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[[Category: Rod domain]]
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[[Category: Structural protein]]
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Current revision

Molecular structure of the rod domain of Dictyostelium filamin

PDB ID 1wlh

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