1fki

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[[Image:1fki.png|left|200px]]
 
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==DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12==
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The line below this paragraph, containing "STRUCTURE_1fki", creates the "Structure Box" on the page.
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<StructureSection load='1fki' size='340' side='right'caption='[[1fki]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SB1:(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0]+PENTACOSANE'>SB1</scene></td></tr>
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{{STRUCTURE_1fki| PDB=1fki | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fki OCA], [https://pdbe.org/1fki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fki RCSB], [https://www.ebi.ac.uk/pdbsum/1fki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fki ProSAT]</span></td></tr>
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</table>
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===DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12===
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== Function ==
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[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[1fki]] is a 2 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKI OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fki_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fki ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cyclophilin]]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bossard, M J.]]
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[[Category: Large Structures]]
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[[Category: Brandt, M.]]
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[[Category: Bossard MJ]]
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[[Category: Clardy, J.]]
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[[Category: Brandt M]]
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[[Category: Eggleston, D S.]]
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[[Category: Clardy J]]
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[[Category: Holt, D A.]]
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[[Category: Eggleston DS]]
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[[Category: Konialian, A L.]]
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[[Category: Holt DA]]
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[[Category: Levy, M A.]]
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[[Category: Konialian AL]]
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[[Category: Liang, J.]]
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[[Category: Levy MA]]
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[[Category: Luengo, J I.]]
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[[Category: Liang J]]
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[[Category: Oh, H J.]]
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[[Category: Luengo JI]]
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[[Category: Rozamus, L W.]]
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[[Category: Oh H-J]]
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[[Category: Schultz, L W.]]
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[[Category: Rozamus LW]]
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[[Category: Stout, T J.]]
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[[Category: Schultz LW]]
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[[Category: Yamashita, D S.]]
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[[Category: Stout TJ]]
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[[Category: Yen, H K.]]
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[[Category: Yamashita DS]]
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[[Category: Cis-trans isomerase]]
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[[Category: Yen H-K]]

Current revision

DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12

PDB ID 1fki

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