3ch5

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[[Image:3ch5.png|left|200px]]
 
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==The crystal structure of the RanGDP-Nup153ZnF2 complex==
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The line below this paragraph, containing "STRUCTURE_3ch5", creates the "Structure Box" on the page.
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<StructureSection load='3ch5' size='340' side='right'caption='[[3ch5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ch5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CH5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ch5| PDB=3ch5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ch5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ch5 OCA], [https://pdbe.org/3ch5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ch5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ch5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ch5 ProSAT]</span></td></tr>
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</table>
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===The crystal structure of the RanGDP-Nup153ZnF2 complex===
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18611384 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/3ch5_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18611384}}
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3ch5]] is a 2 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CH5 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ch5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoporin]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:18611384</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Schrader, N.]]
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[[Category: Schrader N]]
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[[Category: Vetter, I R.]]
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[[Category: Vetter IR]]
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[[Category: Ranbp2 type c2-c2 zinc finger]]
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[[Category: Transport protein]]
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Current revision

The crystal structure of the RanGDP-Nup153ZnF2 complex

PDB ID 3ch5

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