2rcv

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[[Image:2rcv.png|left|200px]]
 
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==Crystal structure of the Bacillus subtilis superoxide dismutase==
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The line below this paragraph, containing "STRUCTURE_2rcv", creates the "Structure Box" on the page.
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<StructureSection load='2rcv' size='340' side='right'caption='[[2rcv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rcv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_2rcv| PDB=2rcv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcv OCA], [https://pdbe.org/2rcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rcv RCSB], [https://www.ebi.ac.uk/pdbsum/2rcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rcv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SODM_BACSU SODM_BACSU] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rcv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rcv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sodA gene of Bacillus subtilis was expressed in Escherichia coli, purified and crystallized. The crystal structure of MnSOD was solved by molecular replacement with four dimers per asymmetric unit and refined to an R factor of 21.1% at 1.8 A resolution. The dimer structure is very similar to that of the related enzyme from B. anthracis. Larger structural differences were observed with the human MnSOD, which has one less helix in the helical domain and a longer loop between two beta-strands and also showed differences in three amino acids at the intersubunit interface in the dimer compared with the two bacterial MnSODs. These structural differences can be exploited in the design of drugs that selectively target the Bacillus enzymes.
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===Crystal structure of the Bacillus subtilis superoxide dismutase===
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Structure of Bacillus subtilis superoxide dismutase.,Liu P, Ewis HE, Huang YJ, Lu CD, Tai PC, Weber IT Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt, 12):1003-7. Epub 2007 Nov 21. PMID:18084079<ref>PMID:18084079</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18084079}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2rcv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18084079 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084079}}
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==About this Structure==
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[[2rcv]] is a 8 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCV OCA].
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==See Also==
==See Also==
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*[[Superoxide Dismutase]]
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:18084079</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Superoxide dismutase]]
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[[Category: Large Structures]]
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[[Category: Ewis, H E.]]
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[[Category: Ewis HE]]
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[[Category: Huang, Y J]]
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[[Category: Huang YJ]]
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[[Category: Liu, P.]]
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[[Category: Liu P]]
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[[Category: Lu, C D]]
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[[Category: Lu CD]]
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[[Category: Tai, P C]]
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[[Category: Tai PC]]
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[[Category: Weber, I T]]
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[[Category: Weber IT]]
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[[Category: Bacillus subtili]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphorylation]]
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[[Category: Stress response]]
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[[Category: Superoxide dismutase]]
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Current revision

Crystal structure of the Bacillus subtilis superoxide dismutase

PDB ID 2rcv

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OCA

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