2qu4

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(New page: 200px<br /><applet load="2qu4" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qu4" /> '''Model for Bacterial ParM Filament'''<br /> ...)
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[[Image:2qu4.jpg|left|200px]]<br /><applet load="2qu4" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qu4" />
 
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'''Model for Bacterial ParM Filament'''<br />
 
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==Overview==
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==Model for Bacterial ParM Filament==
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Bacterial ParM is a homolog of eukaryotic actin and is involved in moving, plasmids so that they segregate properly during cell division. Using, cryo-EM and three-dimensional reconstruction, we show that ParM filaments, have a different structure from F-actin, with very different, subunit-subunit interfaces. These interfaces result in the helical, handedness of the ParM filament being opposite to that of F-actin. Like, F-actin, ParM filaments have a variable twist, and we show that this, involves domain-domain rotations within the ParM subunit. The present, results yield new insights into polymorphisms within F-actin, as well as, the evolution of polymer families.
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<SX load='2qu4' size='340' side='right' viewer='molstar' caption='[[2qu4]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QU4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [https://pdbe.org/2qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qu4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qu4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qu4 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2QU4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA].
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*[[Plasmid segregation protein ParM|Plasmid segregation protein ParM]]
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__TOC__
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==Reference==
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</SX>
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The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17873883 17873883]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Egelman, E.H.]]
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[[Category: Egelman EH]]
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[[Category: Galkin, V.E.]]
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[[Category: Galkin VE]]
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[[Category: Garner, E.C.]]
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[[Category: Garner EC]]
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[[Category: Heuser, J.]]
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[[Category: Heuser J]]
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[[Category: Mullins, R.D.]]
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[[Category: Mullins RD]]
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[[Category: Orlova, A.]]
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[[Category: Orlova A]]
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[[Category: actin-like protein]]
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[[Category: filament model]]
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[[Category: helical polymer]]
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[[Category: plasmid]]
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[[Category: plasmid partition]]
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[[Category: structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:51:20 2008''
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Current revision

Model for Bacterial ParM Filament

2qu4, resolution 16.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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