3fur

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[[Image:3fur.png|left|200px]]
 
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==Crystal Structure of PPARg in complex with INT131==
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The line below this paragraph, containing "STRUCTURE_3fur", creates the "Structure Box" on the page.
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<StructureSection load='3fur' size='340' side='right'caption='[[3fur]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fur]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FUR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=Z12:2,4-DICHLORO-N-[3,5-DICHLORO-4-(QUINOLIN-3-YLOXY)PHENYL]BENZENESULFONAMIDE'>Z12</scene></td></tr>
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{{STRUCTURE_3fur| PDB=3fur | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fur OCA], [https://pdbe.org/3fur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fur RCSB], [https://www.ebi.ac.uk/pdbsum/3fur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fur ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of PPARg in complex with INT131===
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== Disease ==
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref> Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref> Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
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== Function ==
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[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_19452630}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 19452630 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_19452630}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/3fur_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[3fur]] is a 2 chain structure of [[Peroxisome Proliferator-Activated Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FUR OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fur ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Peroxisome Proliferator-Activated Receptors]]
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19452630</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liu, J.]]
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[[Category: Large Structures]]
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[[Category: Walker, N.]]
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[[Category: Synthetic construct]]
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[[Category: Wang, Z.]]
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[[Category: Liu J]]
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[[Category: Activator]]
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[[Category: Walker N]]
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[[Category: Alternative splicing]]
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[[Category: Wang Z]]
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[[Category: Diabetes mellitus]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Int131]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Obesity]]
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[[Category: Partial agonist]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Ppargamma]]
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[[Category: Receptor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-transcription regulator complex]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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Current revision

Crystal Structure of PPARg in complex with INT131

PDB ID 3fur

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OCA

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