2b5f

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[[Image:2b5f.png|left|200px]]
 
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==Crystal structure of the spinach aquaporin SoPIP2;1 in an open conformation to 3.9 resolution==
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The line below this paragraph, containing "STRUCTURE_2b5f", creates the "Structure Box" on the page.
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<StructureSection load='2b5f' size='340' side='right'caption='[[2b5f]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b5f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B5F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b5f OCA], [https://pdbe.org/2b5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b5f RCSB], [https://www.ebi.ac.uk/pdbsum/2b5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b5f ProSAT]</span></td></tr>
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{{STRUCTURE_2b5f| PDB=2b5f | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q41372_SPIOL Q41372_SPIOL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/2b5f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b5f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane. Channel closure results either from the dephosphorylation of two conserved serine residues under conditions of drought stress, or from the protonation of a conserved histidine residue following a drop in cytoplasmic pH due to anoxia during flooding. Here we report the X-ray structure of the spinach plasma membrane aquaporin SoPIP2;1 in its closed conformation at 2.1 A resolution and in its open conformation at 3.9 A resolution, and molecular dynamics simulations of the initial events governing gating. In the closed conformation loop D caps the channel from the cytoplasm and thereby occludes the pore. In the open conformation loop D is displaced up to 16 A and this movement opens a hydrophobic gate blocking the channel entrance from the cytoplasm. These results reveal a molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins.
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===Crystal structure of the spinach aquaporin SoPIP2;1 in an open conformation to 3.9 resolution===
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Structural mechanism of plant aquaporin gating.,Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M, Tajkhorshid E, Neutze R, Kjellbom P Nature. 2006 Feb 9;439(7077):688-94. Epub 2005 Dec 7. PMID:16340961<ref>PMID:16340961</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2b5f" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16340961 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16340961}}
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==About this Structure==
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[[2b5f]] is a 4 chain structure of [[Aquaporin]] with sequence from [http://en.wikipedia.org/wiki/Spinacia_oleracea Spinacia oleracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B5F OCA].
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==See Also==
==See Also==
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*[[Aquaporin]]
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16340961</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Spinacia oleracea]]
[[Category: Spinacia oleracea]]
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[[Category: Hedfalk, K.]]
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[[Category: Hedfalk K]]
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[[Category: Johanson, U.]]
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[[Category: Johanson U]]
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[[Category: Karlsson, M.]]
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[[Category: Karlsson M]]
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[[Category: Kjellbom, P.]]
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[[Category: Kjellbom P]]
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[[Category: Neutze, R.]]
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[[Category: Neutze R]]
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[[Category: Tajkhorshid, E.]]
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[[Category: Tajkhorshid E]]
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[[Category: Tornroth-Horsefield, S.]]
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[[Category: Tornroth-Horsefield S]]
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[[Category: Wang, Y.]]
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[[Category: Wang Y]]
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[[Category: Aquaporin]]
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[[Category: Major intrinsic protein]]
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[[Category: Membrane protein]]
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[[Category: Mip]]
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[[Category: Pip]]
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[[Category: Plasma membrane intrinsic protein]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the spinach aquaporin SoPIP2;1 in an open conformation to 3.9 resolution

PDB ID 2b5f

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