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4est

From Proteopedia

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[[Image:4est.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_4est", creates the "Structure Box" on the page.
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<StructureSection load='4est' size='340' side='right'caption='[[4est]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4est]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4EST FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=FPA:BROMO(DIFLUORO)ACETIC+ACID'>FPA</scene>, <scene name='pdbligand=PEA:2-PHENYLETHYLAMINE'>PEA</scene>, <scene name='pdbligand=VAI:(2S)-2-AMINO-3-METHYLBUTANE-1,1-DIOL'>VAI</scene></td></tr>
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{{STRUCTURE_4est| PDB=4est | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4est FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4est OCA], [http://pdbe.org/4est PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4est RCSB], [http://www.ebi.ac.uk/pdbsum/4est PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4est ProSAT]</span></td></tr>
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===CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION===
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.
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==About this Structure==
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== Evolutionary Conservation ==
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[[4est]] is a 2 chain structure of [[Elastase]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EST OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/4est_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4est ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Elastase]]
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*[[CHEM2052 Tutorial|CHEM2052 Tutorial]]
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*[[Elastase 3D structures|Elastase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pancreatic elastase]]
[[Category: Pancreatic elastase]]
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[[Category: Sus scrofa]]
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[[Category: Pig]]
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[[Category: Meyerjunior, E F.]]
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[[Category: Meyerjunior, E F]]
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[[Category: Radhakrishnan, R.]]
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[[Category: Radhakrishnan, R]]
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[[Category: Rosenfieldjunior, R E.]]
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[[Category: Rosenfieldjunior, R E]]
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[[Category: Takahashi, L H.]]
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[[Category: Takahashi, L H]]
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[[Category: Trainor, D A.]]
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[[Category: Trainor, D A]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Serine proteinase]]

Current revision

CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION

PDB ID 4est

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OCA

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