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1r0z

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[[Image:1r0z.png|left|200px]]
 
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==Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP==
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The line below this paragraph, containing "STRUCTURE_1r0z", creates the "Structure Box" on the page.
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<StructureSection load='1r0z' size='340' side='right'caption='[[1r0z]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r0z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_1r0z| PDB=1r0z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0z OCA], [https://pdbe.org/1r0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0z RCSB], [https://www.ebi.ac.uk/pdbsum/1r0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0z ProSAT]</span></td></tr>
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</table>
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===Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP===
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== Function ==
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[https://www.uniprot.org/uniprot/CFTR_MOUSE CFTR_MOUSE] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_14685259}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14685259 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/1r0z_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14685259}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1r0z]] is a 4 chain structure of [[ABC transporter]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0Z OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0z ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[ABC transporter]]
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*[[ABC transporter 3D structures|ABC transporter 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:14685259</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Buchanan, S G.]]
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[[Category: Buchanan SG]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Conners, K.]]
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[[Category: Conners K]]
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[[Category: Dickey, M.]]
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[[Category: Dickey M]]
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[[Category: Dorwart, M.]]
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[[Category: Dorwart M]]
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[[Category: Fowler, R.]]
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[[Category: Fowler R]]
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[[Category: Gao, X.]]
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[[Category: Gao X]]
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[[Category: Guggino, W B.]]
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[[Category: Guggino WB]]
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[[Category: Hendrickson, W A.]]
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[[Category: Hendrickson WA]]
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[[Category: Lewis, H A.]]
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[[Category: Lewis HA]]
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[[Category: Abc transporter nucleotide binding domain]]
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[[Category: Transport protein]]
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Current revision

Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP

PDB ID 1r0z

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