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1f4u

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[[Image:1f4u.png|left|200px]]
 
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==THERMOPHILIC P450: CYP119 FROM SULFOLOBUS SOLFACTARICUS==
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The line below this paragraph, containing "STRUCTURE_1f4u", creates the "Structure Box" on the page.
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<StructureSection load='1f4u' size='340' side='right'caption='[[1f4u]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f4u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F4U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1f4u| PDB=1f4u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f4u OCA], [https://pdbe.org/1f4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f4u RCSB], [https://www.ebi.ac.uk/pdbsum/1f4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f4u ProSAT]</span></td></tr>
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</table>
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===THERMOPHILIC P450: CYP119 FROM SULFOLOBUS SOLFACTARICUS===
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== Function ==
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[https://www.uniprot.org/uniprot/CP119_SULAC CP119_SULAC] The endogenous substrate is not known. In vitro, catalyzes the H(2)O(2)-dependent epoxidation of styrene, cis-beta-methylstyrene, and cis-stilbene with retention of stereochemistry. Is able to use cumene hydroperoxide (CHP) or tert-butyl hydroperoxide (TBHP) instead of H(2)O(2) as the electron acceptor. Can also hydroxylate fatty acids such as lauric acid.<ref>PMID:10799487</ref> <ref>PMID:12010041</ref> <ref>PMID:18157853</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10859321}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10859321 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/1f4u_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10859321}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1f4u]] is a 2 chain structure of [[Cytochrome P450]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F4U OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f4u ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Cytochrome P450]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:10859321</ref><references group="xtra"/>
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__TOC__
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[[Category: Sulfolobus solfataricus]]
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</StructureSection>
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[[Category: Koo, L S.]]
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[[Category: Large Structures]]
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[[Category: Li, H.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Montellano, P R.Ortiz de.]]
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[[Category: Koo LS]]
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[[Category: Poulos, T L.]]
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[[Category: Li H]]
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[[Category: Schuller, D J.]]
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[[Category: Ortiz de Montellano PR]]
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[[Category: Yano, J K.]]
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[[Category: Poulos TL]]
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[[Category: Oxidoreductase]]
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[[Category: Schuller DJ]]
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[[Category: P450 fold]]
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[[Category: Yano JK]]

Current revision

THERMOPHILIC P450: CYP119 FROM SULFOLOBUS SOLFACTARICUS

PDB ID 1f4u

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