1qz5

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[[Image:1qz5.png|left|200px]]
 
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==Structure of rabbit actin in complex with kabiramide C==
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<StructureSection load='1qz5' size='340' side='right'caption='[[1qz5]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qz5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZ5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=KAB:KABIRAMIDE+C'>KAB</scene></td></tr>
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{{STRUCTURE_1qz5| PDB=1qz5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qz5 OCA], [https://pdbe.org/1qz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qz5 RCSB], [https://www.ebi.ac.uk/pdbsum/1qz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qz5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Marine macrolide toxins of trisoxazole family target actin with high affinity and specificity and have promising pharmacological properties. We present X-ray structures of actin in complex with two members of this family, kabiramide C and jaspisamide A, at a resolution of 1.45 and 1.6 A, respectively. The structures reveal the absolute stereochemistry of these toxins and demonstrate that their trisoxazole ring interacts with actin subdomain 1 while the aliphatic side chain is inserted into the hydrophobic cavity between actin subdomains 1 and 3. The binding site is essentially the same as the one occupied by the actin-capping domain of the gelsolin superfamily of proteins. The structural evidence suggests that actin filament severing and capping by these toxins is also analogous to that of gelsolin. Consequently, these macrolides may be viewed as small molecule biomimetics of an entire class of actin-binding proteins.
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===Structure of rabbit actin in complex with kabiramide C===
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Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin.,Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I Nat Struct Biol. 2003 Dec;10(12):1058-63. Epub 2003 Oct 26. PMID:14578936<ref>PMID:14578936</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1qz5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14578936 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14578936}}
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==About this Structure==
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[[1qz5]] is a 1 chain structure of [[Actin]] with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ5 OCA].
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==See Also==
==See Also==
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*[[Actin]]
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*[[Actin 3D structures|Actin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:14578936</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Allingham, J S.]]
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[[Category: Allingham JS]]
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[[Category: King, R.]]
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[[Category: King R]]
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[[Category: Klenchin, V A.]]
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[[Category: Klenchin VA]]
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[[Category: Marriott, G.]]
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[[Category: Marriott G]]
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[[Category: Rayment, I.]]
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[[Category: Rayment I]]
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[[Category: Tanaka, J.]]
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[[Category: Tanaka J]]
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[[Category: Actin]]
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[[Category: Kabiramide c]]
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[[Category: Structural protein]]
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[[Category: Toxin]]
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[[Category: Trisoxazole]]
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Current revision

Structure of rabbit actin in complex with kabiramide C

PDB ID 1qz5

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