This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1m7t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1m7t" [edit=sysop:move=sysop])
Current revision (08:32, 10 April 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1m7t.png|left|200px]]
 
-
<!--
+
==Solution Structure and Dynamics of the Human-Escherichia coli Thioredoxin Chimera: Insights into Thermodynamic Stability==
-
The line below this paragraph, containing "STRUCTURE_1m7t", creates the "Structure Box" on the page.
+
<StructureSection load='1m7t' size='340' side='right'caption='[[1m7t]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1m7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M7T FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7t OCA], [https://pdbe.org/1m7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m7t RCSB], [https://www.ebi.ac.uk/pdbsum/1m7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m7t ProSAT]</span></td></tr>
-
{{STRUCTURE_1m7t| PDB=1m7t | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Solution Structure and Dynamics of the Human-Escherichia coli Thioredoxin Chimera: Insights into Thermodynamic Stability===
+
[https://www.uniprot.org/uniprot/THIO_ECOLI THIO_ECOLI] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.[https://www.uniprot.org/uniprot/THIO_HUMAN THIO_HUMAN] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref> ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).<ref>PMID:2176490</ref> <ref>PMID:9108029</ref> <ref>PMID:11118054</ref> <ref>PMID:16408020</ref> <ref>PMID:17606900</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_12135359}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12135359 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/1m7t_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_12135359}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m7t ConSurf].
-
[[1m7t]] is a 1 chain structure of [[Thioredoxin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_escherichia_coli Homo sapiens, escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7T OCA].
+
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Thioredoxin]]
+
*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:12135359</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Homo sapiens, escherichia coli]]
+
</StructureSection>
-
[[Category: Dangi, B.]]
+
[[Category: Escherichia coli]]
-
[[Category: Dobrodumov, A V.]]
+
[[Category: Homo sapiens]]
-
[[Category: Gronenborn, A M.]]
+
[[Category: Large Structures]]
-
[[Category: Louis, J M.]]
+
[[Category: Dangi B]]
-
[[Category: Chimera]]
+
[[Category: Dobrodumov AV]]
-
[[Category: Dynamic]]
+
[[Category: Gronenborn AM]]
-
[[Category: E. coli]]
+
[[Category: Louis JM]]
-
[[Category: Electron transport]]
+
-
[[Category: Human]]
+
-
[[Category: Stability]]
+

Current revision

Solution Structure and Dynamics of the Human-Escherichia coli Thioredoxin Chimera: Insights into Thermodynamic Stability

PDB ID 1m7t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m7t"
Personal tools