2bto

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[[Image:2bto.png|left|200px]]
 
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==Structure of BtubA from Prosthecobacter dejongeii==
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The line below this paragraph, containing "STRUCTURE_2bto", creates the "Structure Box" on the page.
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<StructureSection load='2bto' size='340' side='right'caption='[[2bto]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bto]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Prosthecobacter_dejongeii Prosthecobacter dejongeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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{{STRUCTURE_2bto| PDB=2bto | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bto OCA], [https://pdbe.org/2bto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bto RCSB], [https://www.ebi.ac.uk/pdbsum/2bto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bto ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8GCC5_9BACT Q8GCC5_9BACT]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2bto_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bto ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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alphabeta-Tubulin heterodimers, from which the microtubules of the cytoskeleton are built, have a complex chaperone-dependent folding pathway. They are thought to be unique to eukaryotes, whereas the homologue FtsZ can be found in bacteria. The exceptions are BtubA and BtubB from Prosthecobacter, which have higher sequence homology to eukaryotic tubulin than to FtsZ. Here we show that some of their properties are different from tubulin, such as weak dimerization and chaperone-independent folding. However, their structure is strikingly similar to tubulin including surface loops, and BtubA/B form tubulin-like protofilaments. Presumably, BtubA/B were transferred from a eukaryotic cell by horizontal gene transfer because their high degree of similarity to eukaryotic genes is unique within the Prosthecobacter genome.
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===STRUCTURE OF BTUBA FROM PROSTHECOBACTER DEJONGEII===
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Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer.,Schlieper D, Oliva MA, Andreu JM, Lowe J Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9170-5. Epub 2005 Jun 20. PMID:15967998<ref>PMID:15967998</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15967998}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bto" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15967998 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15967998}}
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==About this Structure==
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[[2bto]] is a 3 chain structure of [[Thioredoxin]] and [[Tubulin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Prosthecobacter_dejongeii Prosthecobacter dejongeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTO OCA].
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==See Also==
==See Also==
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*[[Thioredoxin]]
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*[[BtuB 3D structures|BtuB 3D structures]]
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*[[Tubulin]]
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:15967998</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Large Structures]]
[[Category: Prosthecobacter dejongeii]]
[[Category: Prosthecobacter dejongeii]]
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[[Category: Lowe, J.]]
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[[Category: Lowe J]]
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[[Category: Schlieper, D.]]
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[[Category: Schlieper D]]
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[[Category: Bacterial tubulin]]
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[[Category: Cytoskeletal protein]]
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[[Category: Cytoskeleton]]
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[[Category: Polymerization]]
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[[Category: Protein complex]]
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Current revision

Structure of BtubA from Prosthecobacter dejongeii

PDB ID 2bto

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OCA

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