1kql

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[[Image:1kql.png|left|200px]]
 
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==Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution==
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The line below this paragraph, containing "STRUCTURE_1kql", creates the "Structure Box" on the page.
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<StructureSection load='1kql' size='340' side='right'caption='[[1kql]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kql]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kql OCA], [https://pdbe.org/1kql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kql RCSB], [https://www.ebi.ac.uk/pdbsum/1kql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kql ProSAT]</span></td></tr>
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{{STRUCTURE_1kql| PDB=1kql | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution===
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[https://www.uniprot.org/uniprot/TPM1_RAT TPM1_RAT] Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12032291 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/1kql_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_12032291}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kql ConSurf].
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[[1kql]] is a 2 chain structure of [[Tropomyosin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae,_rattus_norvegicus Saccharomyces cerevisiae, rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQL OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Tropomyosin]]
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*[[Gcn4 3D Structures|Gcn4 3D Structures]]
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*[[Gnc4 3D Structures|Gnc4 3D Structures]]
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==Reference==
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*[[Tropomyosin 3D structures|Tropomyosin 3D structures]]
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<ref group="xtra">PMID:12032291</ref><references group="xtra"/>
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__TOC__
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[[Category: Saccharomyces cerevisiae, rattus norvegicus]]
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</StructureSection>
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[[Category: Brown, J H.]]
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[[Category: Large Structures]]
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[[Category: Cohen, C.]]
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[[Category: Rattus norvegicus]]
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[[Category: Li, Y.]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Mui, S.]]
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[[Category: Brown JH]]
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[[Category: Reshetnikova, L.]]
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[[Category: Cohen C]]
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[[Category: Strand, J.]]
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[[Category: Li Y]]
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[[Category: Tobacman, L S.]]
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[[Category: Mui S]]
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[[Category: Coiled coil]]
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[[Category: Reshetnikova L]]
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[[Category: Contractile protein]]
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[[Category: Strand J]]
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[[Category: Four-helix bundle]]
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[[Category: Tobacman LS]]
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[[Category: Muscle regulation]]
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[[Category: Thin filament]]
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[[Category: Tropomyosin]]
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Current revision

Crystal structure of the C-terminal region of striated muscle alpha-tropomyosin at 2.7 angstrom resolution

PDB ID 1kql

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