2xq7

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[[Image:2xq7.png|left|200px]]
 
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==Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+)==
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The line below this paragraph, containing "STRUCTURE_2xq7", creates the "Structure Box" on the page.
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<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_2xq7| PDB=2xq7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [https://pdbe.org/2xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The flow of ions through cation-selective members of the pentameric ligand-gated ion channel family is inhibited by a structurally diverse class of molecules that bind to the transmembrane pore in the open state of the protein. To obtain insight into the mechanism of channel block, we have investigated the binding of positively charged inhibitors to the open channel of the bacterial homolog GLIC by using X-ray crystallography and electrophysiology. Our studies reveal the location of two regions for interactions, with larger blockers binding in the center of the membrane and divalent transition metal ions binding to the narrow intracellular pore entry. The results provide a structural foundation for understanding the interactions of the channel with inhibitors that is relevant for the entire family.
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===PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH CADMIUM ION (CD2+)===
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Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.,Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R Nat Struct Mol Biol. 2010 Nov;17(11):1330-1336. Epub 2010 Oct 31. PMID:21037567<ref>PMID:21037567</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2xq7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21037567 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21037567}}
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==About this Structure==
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[[2xq7]] is a 5 chain structure of [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].
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==See Also==
==See Also==
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*[[Ion channels (Part II)]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:21037567</ref><ref group="xtra">PMID:18987630</ref><references group="xtra"/>
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__TOC__
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[[Category: Gloeobacter violaceus pcc 7421]]
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</StructureSection>
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[[Category: Bertozzi, C.]]
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[[Category: Gloeobacter violaceus PCC 7421]]
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[[Category: Dutzler, R.]]
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[[Category: Large Structures]]
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[[Category: Hilf, R J.C.]]
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[[Category: Bertozzi C]]
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[[Category: Reiter, A.]]
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[[Category: Dutzler R]]
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[[Category: Trauner, D.]]
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[[Category: Hilf RJC]]
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[[Category: Zimmermann, I.]]
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[[Category: Reiter A]]
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[[Category: Membrane protein]]
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[[Category: Trauner D]]
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[[Category: Open channel block]]
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[[Category: Zimmermann I]]

Current revision

Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+)

PDB ID 2xq7

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