3f57

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[[Image:3f57.png|left|200px]]
 
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==Crystal structure of human erythroid beta spectrin repeats 14 and 15 (ankyrin binding domain)==
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The line below this paragraph, containing "STRUCTURE_3f57", creates the "Structure Box" on the page.
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<StructureSection load='3f57' size='340' side='right'caption='[[3f57]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3f57]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F57 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f57 OCA], [https://pdbe.org/3f57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f57 RCSB], [https://www.ebi.ac.uk/pdbsum/3f57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f57 ProSAT]</span></td></tr>
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{{STRUCTURE_3f57| PDB=3f57 | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Defects in SPTB are the cause of elliptocytosis type 3 (EL3) [MIM:[https://omim.org/entry/182870 182870]. EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.<ref>PMID:8226774</ref> <ref>PMID:7883966</ref> <ref>PMID:8018926</ref> <ref>PMID:1975598</ref> Defects in SPTB are the cause of spherocytosis type 2 (SPH2) [MIM:[https://omim.org/entry/182870 182870]; also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant.
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== Function ==
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[https://www.uniprot.org/uniprot/SPTB1_HUMAN SPTB1_HUMAN] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/3f57_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f57 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As key components of the erythrocyte membrane skeleton, spectrin and ankyrin specifically interact to tether the spectrin cytoskeleton to the cell membrane. The structure of the spectrin binding domain of ankyrin and the ankyrin binding domain of spectrin have been solved to elucidate the structural basis for ankyrin-spectrin recognition. The structure of repeats 14 and 15 of spectrin shows that these repeats are similar to all other spectrin repeats. One feature that could account for the preference of ankyrin for these repeats is the presence of a conserved, negatively charged patch on one side of repeat 14. The structure of the ankyrin ZU5 domain shows a novel structure containing a beta core. The structure reveals that the canonical ZU5 consensus sequence is likely to be missing an important region that codes for a beta strand that forms part of the core of the domain. In addition, a positively charged region is suggestive of a binding surface for the negatively charged spectrin repeat 14. Previously reported mutants of ankyrin that map to this region lie mostly on the surface of the protein, although at least one is likely to be part of the core.
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===Crystal structure of human erythroid beta spectrin repeats 14 and 15 (ankyrin binding domain)===
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Structures of the spectrin-ankyrin interaction binding domains.,Ipsaro JJ, Huang L, Mondragon A Blood. 2009 May 28;113(22):5385-93. Epub 2009 Jan 13. PMID:19141864<ref>PMID:19141864</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3f57" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19141864 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19141864}}
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==About this Structure==
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[[3f57]] is a 2 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F57 OCA].
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==See Also==
==See Also==
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*[[Spectrin]]
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19141864</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ipsaro, J J.]]
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[[Category: Large Structures]]
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[[Category: Mondragon, A.]]
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[[Category: Ipsaro JJ]]
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[[Category: Actin capping]]
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[[Category: Mondragon A]]
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[[Category: Actin-binding]]
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[[Category: Alternative splicing]]
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[[Category: Ankyrin binding]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Disease mutation]]
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[[Category: Elliptocytosis]]
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[[Category: Hereditary hemolytic anemia]]
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[[Category: Phosphoprotein]]
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[[Category: Spectrin]]
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[[Category: Spectrin repeat]]
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[[Category: Structural protein]]
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[[Category: Three-helix-bundle]]
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Current revision

Crystal structure of human erythroid beta spectrin repeats 14 and 15 (ankyrin binding domain)

PDB ID 3f57

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