1sa0

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[[Image:1sa0.png|left|200px]]
 
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==TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1sa0", creates the "Structure Box" on the page.
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<StructureSection load='1sa0' size='340' side='right'caption='[[1sa0]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sa0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SA0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN2:2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE'>CN2</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1sa0| PDB=1sa0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sa0 OCA], [https://pdbe.org/1sa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sa0 ProSAT]</span></td></tr>
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</table>
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===TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX===
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== Function ==
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[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15014504}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15014504 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sa0_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15014504}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1sa0]] is a 5 chain structure of [[Tubulin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA0 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sa0 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Tubulin]]
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*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
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*[[Tubulin 3D Structures|Tubulin 3D Structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:15014504</ref><references group="xtra"/>
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Curmi, P A.]]
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[[Category: Curmi PA]]
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[[Category: Gigant, B.]]
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[[Category: Gigant B]]
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[[Category: Jourdain, I.]]
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[[Category: Jourdain I]]
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[[Category: Knossow, M.]]
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[[Category: Knossow M]]
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[[Category: Lachkar, S.]]
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[[Category: Lachkar S]]
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[[Category: Ravelli, R B.]]
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[[Category: Ravelli RB]]
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[[Category: Sobel, A.]]
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[[Category: Sobel A]]
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[[Category: Alpha-tubulin]]
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[[Category: Beta-tubulin]]
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[[Category: Cell cycle]]
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[[Category: Colchicine]]
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[[Category: Gtpase]]
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[[Category: Microtubule podophyllotoxin]]
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[[Category: Stathmin]]
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[[Category: Tubulin]]
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Current revision

TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX

PDB ID 1sa0

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