3o4m

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[[Image:3o4m.png|left|200px]]
 
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==Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene==
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The line below this paragraph, containing "STRUCTURE_3o4m", creates the "Structure Box" on the page.
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<StructureSection load='3o4m' size='340' side='right'caption='[[3o4m]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAQ:CATECHOL'>CAQ</scene></td></tr>
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{{STRUCTURE_3o4m| PDB=3o4m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4m OCA], [https://pdbe.org/3o4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4m RCSB], [https://www.ebi.ac.uk/pdbsum/3o4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o4/3o4m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o4m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Inhibiting PLA(2) activity should, in theory, be an effective approach to control the inflammation. Several naturally occurring polyphenolic compounds have been reported as inhibitors of PLA(2) . Among the naturally occurring polyphenols, catechol (1,2-dihydroxybenzene) possesses anti-inflammatory activity. Catechol can inhibit cyclooxygenase and lipo-oxygenase. By means of enzyme kinetic study, it was revealed that catechol can inhibit PLA(2) also. Crystal structure showed that catechol binds to PLA(2) at the opening of the active site cleft. This might stop the entry of substrate into the active site. Hence, catechol can be used as a lead compound for the development of novel anti-inflammatory drugs with PLA(2) as the target.
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===Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene===
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Binding to PLA(2) May Contribute to the Anti-Inflammatory Activity of Catechol.,Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C Chem Biol Drug Des. 2011 Oct 13. doi: 10.1111/j.1747-0285.2011.01258.x. PMID:21995306<ref>PMID:21995306</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3o4m]] is a 1 chain structure of [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4M OCA].
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<div class="pdbe-citations 3o4m" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Dileep, K V.]]
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[[Category: Dileep KV]]
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[[Category: Haridas, M.]]
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[[Category: Haridas M]]
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[[Category: Karthe, P.]]
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[[Category: Karthe P]]
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[[Category: Mandal, P K.]]
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[[Category: Mandal PK]]
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[[Category: Sadasivan, C.]]
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[[Category: Sadasivan C]]
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[[Category: Tintu, G.]]
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[[Category: Tintu I]]
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[[Category: Catechol binding]]
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[[Category: Disulfide bond]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Lipoprotein]]
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[[Category: Metal-binding]]
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[[Category: Palmitate]]
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[[Category: Pancrea]]
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[[Category: Pancreatic enzyme]]
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[[Category: Pla2]]
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[[Category: Pyrrolidone carboxylic acid]]
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Current revision

Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene

PDB ID 3o4m

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