3lc6

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[[Image:3lc6.png|left|200px]]
 
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==The alternative conformation structure of isocitrate dehydrogenase kinase/phosphatase from E. Coli==
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The line below this paragraph, containing "STRUCTURE_3lc6", creates the "Structure Box" on the page.
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<StructureSection load='3lc6' size='340' side='right'caption='[[3lc6]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LC6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3lc6| PDB=3lc6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lc6 OCA], [https://pdbe.org/3lc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lc6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lc6 ProSAT]</span></td></tr>
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</table>
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===The alternative conformation structure of isocitrate dehydrogenase kinase/phosphatase from E. Coli===
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== Function ==
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[https://www.uniprot.org/uniprot/ACEK_ECO57 ACEK_ECO57] Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20505668 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lc/3lc6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20505668}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3lc6]] is a 2 chain structure of [[Isocitrate dehydrogenase kinase/phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LC6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lc6 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Isocitrate dehydrogenase kinase/phosphatase]]
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*[[Isocitrate dehydrogenase kinase/phosphatase|Isocitrate dehydrogenase kinase/phosphatase]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:20505668</ref><references group="xtra"/>
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[[Category: Escherichia coli O157:H7]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Jia, Z.]]
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[[Category: Jia Z]]
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[[Category: Zheng, J.]]
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[[Category: Zheng J]]
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[[Category: Atp-binding]]
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[[Category: Glyoxylate bypass]]
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[[Category: Hydrolase]]
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[[Category: Kinase]]
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[[Category: Kinase phosphatase]]
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[[Category: Nadp]]
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[[Category: Nucleotide-binding]]
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[[Category: Protein phosphatase]]
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[[Category: Transferase]]
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[[Category: Tricarboxylic acid cycle]]
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Current revision

The alternative conformation structure of isocitrate dehydrogenase kinase/phosphatase from E. Coli

PDB ID 3lc6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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