1den

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[[Image:1den.png|left|200px]]
 
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==PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS==
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The line below this paragraph, containing "STRUCTURE_1den", creates the "Structure Box" on the page.
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<StructureSection load='1den' size='340' side='right'caption='[[1den]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1den]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1den FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1den OCA], [https://pdbe.org/1den PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1den RCSB], [https://www.ebi.ac.uk/pdbsum/1den PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1den ProSAT]</span></td></tr>
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{{STRUCTURE_1den| PDB=1den | SCENE= }}
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</table>
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== Function ==
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===PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS===
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[https://www.uniprot.org/uniprot/VKTH1_DENPO VKTH1_DENPO] Serine protease inhibitor homolog that blocks voltage-gated potassium channels (Kv1.1/KCNA1, Kv1.2/KCNA2, and Kv1.6/KCNA6) (IC(50)=0.13-50 nM).<ref>PMID:8612784</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 7544683 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1den_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1den ConSurf].
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[[1den]] is a 1 chain structure of [[Dendrotoxin]] and [[Disintegrin]] with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEN OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dendrotoxin]]
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*[[Dendrotoxin|Dendrotoxin]]
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*[[Disintegrin]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:7544683</ref><references group="xtra"/>
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</StructureSection>
[[Category: Dendroaspis polylepis polylepis]]
[[Category: Dendroaspis polylepis polylepis]]
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[[Category: Foray, M F.]]
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[[Category: Large Structures]]
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[[Category: Lancelin, J M.]]
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[[Category: Foray M-F]]
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[[Category: Lancelin J-M]]

Current revision

PROTEINASE INHIBITOR HOMOLOGUES AS POTASSIUM CHANNEL BLOCKERS

PDB ID 1den

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