1ej9

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[[Image:1ej9.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1ej9", creates the "Structure Box" on the page.
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<StructureSection load='1ej9' size='340' side='right'caption='[[1ej9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ej9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EJ9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ej9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ej9 OCA], [https://pdbe.org/1ej9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ej9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ej9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ej9 ProSAT]</span></td></tr>
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{{STRUCTURE_1ej9| PDB=1ej9 | SCENE= }}
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</table>
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== Disease ==
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===CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX===
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[https://www.uniprot.org/uniprot/TOP1_HUMAN TOP1_HUMAN] Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98.
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== Function ==
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[https://www.uniprot.org/uniprot/TOP1_HUMAN TOP1_HUMAN] Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:2833744</ref> <ref>PMID:19168442</ref> <ref>PMID:14594810</ref> <ref>PMID:16033260</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10841763 is the PubMed ID number.
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Check<jmol>
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{{ABSTRACT_PUBMED_10841763}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/1ej9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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[[1ej9]] is a 3 chain structure of [[Topoisomerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ9 OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ej9 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:10841763</ref><references group="xtra"/>
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__TOC__
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[[Category: DNA topoisomerase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Champoux, J J.]]
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[[Category: Large Structures]]
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[[Category: Hol, W G.]]
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[[Category: Champoux JJ]]
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[[Category: Redinbo, M R.]]
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[[Category: Hol WG]]
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[[Category: Human]]
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[[Category: Redinbo MR]]
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[[Category: Isomerase/dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: Type i topoisomerase]]
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Current revision

CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX

PDB ID 1ej9

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