2q5k

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[[Image:2q5k.png|left|200px]]
 
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==Crystal structure of lopinavir bound to wild type HIV-1 protease==
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The line below this paragraph, containing "STRUCTURE_2q5k", creates the "Structure Box" on the page.
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<StructureSection load='2q5k' size='340' side='right'caption='[[2q5k]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2q5k| PDB=2q5k | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5k OCA], [https://pdbe.org/2q5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5k RCSB], [https://www.ebi.ac.uk/pdbsum/2q5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O38710_9HIV1 O38710_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5k ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of lopinavir bound to wild type HIV-1 protease===
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17696512}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17696512 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17696512}}
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==About this Structure==
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[[2q5k]] is a 2 chain structure of [[]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5K OCA].
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==Reference==
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<ref group="xtra">PMID:17696512</ref><references group="xtra"/>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Nalam, M N.L.]]
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[[Category: Large Structures]]
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[[Category: Schiffer, C A.]]
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[[Category: Nalam MNL]]
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[[Category: Drug design]]
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[[Category: Schiffer CA]]
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[[Category: Hiv-1 protease]]
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[[Category: Hydrolase]]
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[[Category: Protease inhibitor]]
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Current revision

Crystal structure of lopinavir bound to wild type HIV-1 protease

PDB ID 2q5k

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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