2p7t
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="2p7t" size="350" color="white" frame="true" align="right" spinBox="true" caption="2p7t, resolution 2.050Å" /> '''Crystal Structure o...) |
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| - | [[Image:2p7t.gif|left|200px]]<br /><applet load="2p7t" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2p7t, resolution 2.050Å" /> | ||
| - | '''Crystal Structure of KcsA mutant'''<br /> | ||
| - | == | + | ==Crystal Structure of KcsA mutant== |
| - | + | <StructureSection load='2p7t' size='340' side='right'caption='[[2p7t]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2p7t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1EM:(1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL+MYRISTATE'>1EM</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7t OCA], [https://pdbe.org/2p7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7t RCSB], [https://www.ebi.ac.uk/pdbsum/2p7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/2p7t_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p7t ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Single protein]] | ||
[[Category: Streptomyces lividans]] | [[Category: Streptomyces lividans]] | ||
| - | [[Category: Cordero-Morales | + | [[Category: Cordero-Morales JF]] |
| - | [[Category: Cortes | + | [[Category: Cortes DM]] |
| - | [[Category: Lewis | + | [[Category: Lewis A]] |
| - | [[Category: Perozo | + | [[Category: Perozo E]] |
| - | [[Category: Roux | + | [[Category: Roux B]] |
| - | [[Category: Valeria | + | [[Category: Valeria VR]] |
| - | [[Category: Vishwanath | + | [[Category: Vishwanath J]] |
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Current revision
Crystal Structure of KcsA mutant
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