3mwp

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[[Image:3mwp.png|left|200px]]
 
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==Nucleoprotein structure of lassa fever virus==
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The line below this paragraph, containing "STRUCTURE_3mwp", creates the "Structure Box" on the page.
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<StructureSection load='3mwp' size='340' side='right'caption='[[3mwp]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mwp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.795&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3mwp| PDB=3mwp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwp OCA], [https://pdbe.org/3mwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwp RCSB], [https://www.ebi.ac.uk/pdbsum/3mwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).
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===Nucleoprotein structure of lassa fever virus===
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_21085117}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21085117 is the PubMed ID number.
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[[Category: Lassa virus Josiah]]
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[[Category: Dong C]]
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{{ABSTRACT_PUBMED_21085117}}
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[[Category: Dong H]]
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[[Category: Lan S]]
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==About this Structure==
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[[Category: Liang Y]]
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[[3mwp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWP OCA].
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[[Category: Ly H]]
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[[Category: Qi X]]
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==Reference==
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[[Category: Schelde LM]]
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<ref group="xtra">PMID:21085117</ref><references group="xtra"/>
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[[Category: Wallat G]]
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[[Category: Lassa virus josiah]]
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[[Category: Wang W]]
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[[Category: Dong, C.]]
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[[Category: Dong, H.]]
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[[Category: Lan, S.]]
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[[Category: Liang, Y.]]
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[[Category: Ly, H.]]
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[[Category: Qi, X.]]
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[[Category: SSPF, Scottish Structural Proteomics Facility.]]
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[[Category: Schelde, L M.]]
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[[Category: Wallat, G.]]
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[[Category: Wang, W.]]
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[[Category: Nuclear protein]]
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[[Category: Nucleoprotein]]
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[[Category: Scottish structural proteomics facility]]
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[[Category: Sspf]]
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[[Category: Structural genomic]]
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Current revision

Nucleoprotein structure of lassa fever virus

PDB ID 3mwp

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OCA

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