2reo

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[[Image:2reo.jpg|left|200px]]<br /><applet load="2reo" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2reo, resolution 2.651&Aring;" />
 
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'''Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP'''<br />
 
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==About this Structure==
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==Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP==
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2REO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=A3P:'>A3P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA].
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<StructureSection load='2reo' size='340' side='right'caption='[[2reo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2reo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.651&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2reo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reo OCA], [https://pdbe.org/2reo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2reo RCSB], [https://www.ebi.ac.uk/pdbsum/2reo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2reo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ST1C3_HUMAN ST1C3_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.<ref>PMID:17936463</ref> <ref>PMID:17425406</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2reo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2reo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dong, A.]]
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[[Category: Dong A]]
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[[Category: Edwards, A.M.]]
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[[Category: Edwards AM]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau P]]
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[[Category: Pan, P.]]
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[[Category: Pan P]]
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[[Category: Plotnikov, A.N.]]
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[[Category: Plotnikov AN]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: A3P]]
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[[Category: alternative splicing]]
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[[Category: cytoplasm]]
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[[Category: pap]]
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[[Category: polymorphism]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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[[Category: sulfate conjugation]]
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[[Category: sulfotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:02:16 2008''
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Current revision

Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP

PDB ID 2reo

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