2ysq

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[[Image:2ysq.jpg|left|200px]]<br /><applet load="2ysq" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2ysq" />
 
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'''Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9'''<br />
 
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==About this Structure==
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==Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9==
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2YSQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YSQ OCA].
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<StructureSection load='2ysq' size='340' side='right'caption='[[2ysq]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2ysq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YSQ FirstGlance]. <br>
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[[Category: Hayashi, F.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Qin, X.R.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ysq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ysq OCA], [https://pdbe.org/2ysq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ysq RCSB], [https://www.ebi.ac.uk/pdbsum/2ysq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ysq ProSAT], [https://www.topsan.org/Proteins/RSGI/2ysq TOPSAN]</span></td></tr>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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</table>
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[[Category: Yokoyama, S.]]
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== Disease ==
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[[Category: national project on protein structural and functional analyses]]
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[https://www.uniprot.org/uniprot/ARHG9_HUMAN ARHG9_HUMAN] Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8) [MIM:[https://omim.org/entry/300607 300607]. A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion.<ref>PMID:15215304</ref>
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[[Category: nppsfa]]
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== Function ==
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[[Category: riken structural genomics/proteomics initiative]]
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[https://www.uniprot.org/uniprot/ARHG9_HUMAN ARHG9_HUMAN] Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.<ref>PMID:10559246</ref>
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[[Category: rsgi]]
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== Evolutionary Conservation ==
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[[Category: sh3 domain; cdc42 guanine nucleotide exchange factor (gef) 9]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: signaling protein]]
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Check<jmol>
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[[Category: structural genomics]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/2ysq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ysq ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:03:34 2008''
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==See Also==
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Hayashi F]]
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[[Category: Qin XR]]
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[[Category: Yokoyama S]]

Current revision

Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9

PDB ID 2ysq

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