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2x13

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[[Image:2x13.jpg|left|200px]]
 
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==The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with ADP and 3phosphoglycerate==
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The line below this paragraph, containing "STRUCTURE_2x13", creates the "Structure Box" on the page.
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<StructureSection load='2x13' size='340' side='right'caption='[[2x13]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2x13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X13 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2x13| PDB=2x13 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x13 OCA], [https://pdbe.org/2x13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x13 RCSB], [https://www.ebi.ac.uk/pdbsum/2x13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x13 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
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===THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE IN COMPLEX WITH ADP AND 3PHOSPHOGLYCERATE===
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==See Also==
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*[[Phosphoglycerate kinase 3D structures|Phosphoglycerate kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2x13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X13 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoglycerate kinase]]
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[[Category: Large Structures]]
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[[Category: Baxter, N J.]]
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[[Category: Baxter NJ]]
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[[Category: Blackburn, G M.]]
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[[Category: Blackburn GM]]
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[[Category: Bowler, M W.]]
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[[Category: Bowler MW]]
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[[Category: Cliff, M J.]]
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[[Category: Cliff MJ]]
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[[Category: Hownslow, A M.H.]]
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[[Category: Hownslow AMH]]
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[[Category: Marston, J P.M.]]
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[[Category: Marston JPM]]
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[[Category: Szabo, J.]]
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[[Category: Szabo J]]
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[[Category: Varga, A V.]]
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[[Category: Varga AV]]
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[[Category: Vas, M.]]
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[[Category: Vas M]]
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[[Category: Waltho, J P.]]
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[[Category: Waltho JP]]
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[[Category: Atp-binding]]
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[[Category: Disease mutation]]
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[[Category: Glycolysis]]
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[[Category: Hereditary hemolytic anemia]]
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[[Category: Kinase]]
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[[Category: Transferase]]
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[[Category: Transition state analogue]]
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Current revision

The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with ADP and 3phosphoglycerate

PDB ID 2x13

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