2xvo

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[[Image:2xvo.jpg|left|200px]]
 
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==SSO1725, a protein involved in the CRISPR/Cas pathway==
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The line below this paragraph, containing "STRUCTURE_2xvo", creates the "Structure Box" on the page.
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<StructureSection load='2xvo' size='340' side='right'caption='[[2xvo]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xvo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2xvo| PDB=2xvo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvo OCA], [https://pdbe.org/2xvo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvo RCSB], [https://www.ebi.ac.uk/pdbsum/2xvo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CMR7B_SACS2 CMR7B_SACS2] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invading viruses and incorporated into ribonucleoprotein complexes with CRISPR-associated (CAS) proteins, to target and degrade viral DNA or RNA on subsequent infection. RNA is targeted by the CMR complex. In Sulfolobus solfataricus, this complex is composed of seven CAS protein subunits (Cmr1-7) and carries a diverse "payload" of targeting crRNA. The crystal structure of Cmr7 and low-resolution structure of the complex are presented. S. solfataricus CMR cleaves RNA targets in an endonucleolytic reaction at UA dinucleotides. This activity is dependent on the 8 nt repeat-derived 5' sequence in the crRNA, but not on the presence of a protospacer-associated motif (PAM) in the target. Both target and guide RNAs can be cleaved, although a single molecule of guide RNA can support the degradation of multiple targets.
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===SSO1725, A PROTEIN INVOLVED IN THE CRISPR/CAS PATHWAY===
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Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity.,Zhang J, Rouillon C, Kerou M, Reeks J, Brugger K, Graham S, Reimann J, Cannone G, Liu H, Albers SV, Naismith JH, Spagnolo L, White MF Mol Cell. 2012 Feb 10;45(3):303-13. doi: 10.1016/j.molcel.2011.12.013. Epub 2012 , Jan 5. PMID:22227115<ref>PMID:22227115</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[2xvo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVO OCA].
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<div class="pdbe-citations 2xvo" style="background-color:#fffaf0;"></div>
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[[Category: Sulfolobus solfataricus]]
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== References ==
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[[Category: Liu, H.]]
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<references/>
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[[Category: Mcmahon, S.]]
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__TOC__
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[[Category: Naismith, J.]]
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</StructureSection>
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[[Category: Reeks, J.]]
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[[Category: Large Structures]]
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[[Category: White, M.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Structural genomic]]
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[[Category: Liu H]]
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[[Category: McMahon S]]
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[[Category: Naismith J]]
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[[Category: Reeks J]]
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[[Category: White M]]

Current revision

SSO1725, a protein involved in the CRISPR/Cas pathway

PDB ID 2xvo

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