2z5d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:56, 13 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2z5d.gif|left|200px]]<br /><applet load="2z5d" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2z5d, resolution 2.10&Aring;" />
 
-
'''Human ubiquitin-conjugating enzyme E2 H'''<br />
 
-
==About this Structure==
+
==Human ubiquitin-conjugating enzyme E2 H==
-
2Z5D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entry 1YH6. Active as [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA].
+
<StructureSection load='2z5d' size='340' side='right'caption='[[2z5d]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2z5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yh6 1yh6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5D FirstGlance]. <br>
-
[[Category: Ubiquitin--protein ligase]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
[[Category: Arrowsmith, C.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
[[Category: Battaile, K.P.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5d OCA], [https://pdbe.org/2z5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5d RCSB], [https://www.ebi.ac.uk/pdbsum/2z5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5d ProSAT]</span></td></tr>
-
[[Category: Bochkarev, A.]]
+
</table>
-
[[Category: Cui, H.]]
+
== Function ==
-
[[Category: Dhe-Paganon, S.]]
+
[https://www.uniprot.org/uniprot/UBE2H_HUMAN UBE2H_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.<ref>PMID:8132613</ref> <ref>PMID:20061386</ref>
-
[[Category: Edwards, A.]]
+
== Evolutionary Conservation ==
-
[[Category: Mackenzie, F.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Newman, E.M.]]
+
Check<jmol>
-
[[Category: SGC, Structural.Genomics.Consortium.]]
+
<jmolCheckbox>
-
[[Category: Sundstrom, M.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5d_consurf.spt"</scriptWhenChecked>
-
[[Category: Walker, J.R.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: NA]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: ligase]]
+
</jmolCheckbox>
-
[[Category: sgc]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5d ConSurf].
-
[[Category: structural genomics]]
+
<div style="clear:both"></div>
-
[[Category: structural genomics consortium]]
+
-
[[Category: ube2h]]
+
-
[[Category: ubiquitin]]
+
-
[[Category: ubiquitin-conjugating enzyme]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:06:05 2008''
+
==See Also==
 +
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Battaile KP]]
 +
[[Category: Bochkarev A]]
 +
[[Category: Cui H]]
 +
[[Category: Dhe-Paganon S]]
 +
[[Category: Edwards A]]
 +
[[Category: Mackenzie F]]
 +
[[Category: Newman EM]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Walker JR]]

Current revision

Human ubiquitin-conjugating enzyme E2 H

PDB ID 2z5d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z5d"
Personal tools