3owi

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[[Image:3owi.jpg|left|200px]]
 
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==Crystal structure of the glycine riboswitch bound to glycine==
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The line below this paragraph, containing "STRUCTURE_3owi", creates the "Structure Box" on the page.
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<StructureSection load='3owi' size='340' side='right'caption='[[3owi]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3owi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_MJ-1236 Vibrio cholerae MJ-1236]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OWI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.845&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3owi| PDB=3owi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3owi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3owi OCA], [https://pdbe.org/3owi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3owi RCSB], [https://www.ebi.ac.uk/pdbsum/3owi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3owi ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Glycine riboswitches regulate gene expression by feedback modulation in response to cooperative binding to glycine. Here, we report on crystal structures of the second glycine-sensing domain from the Vibrio cholerae riboswitch in the ligand-bound and unbound states. This domain adopts a three-helical fold that centers on a three-way junction and accommodates glycine within a bulge-containing binding pocket above the junction. Glycine recognition is facilitated by a pair of bound Mg(2+) cations and governed by specific interactions and shape complementarity with the pocket. A conserved adenine extrudes from the binding pocket and intercalates into the junction implying that glycine binding in the context of the complete riboswitch could impact on gene expression by stabilizing the riboswitch junction and regulatory P1 helix. Analysis of riboswitch interactions in the crystal and footprinting experiments indicates that adjacent glycine-sensing modules of the riboswitch could form specific interdomain interactions, thereby potentially contributing to the cooperative response.
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===Crystal structure of the glycine riboswitch bound to glycine===
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Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch.,Huang L, Serganov A, Patel DJ Mol Cell. 2010 Dec 10;40(5):774-86. PMID:21145485<ref>PMID:21145485</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3owi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21145485}}, adds the Publication Abstract to the page
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21145485 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21145485}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3owi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OWI OCA].
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[[Category: Vibrio cholerae MJ-1236]]
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[[Category: Huang L]]
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==Reference==
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[[Category: Patel DJ]]
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<ref group="xtra">PMID:21145485</ref><references group="xtra"/>
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[[Category: Serganov A]]
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[[Category: Huang, L.]]
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[[Category: Patel, D J.]]
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[[Category: Serganov, A.]]
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[[Category: Gene expression regulator]]
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[[Category: Glycine riboswitch]]
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[[Category: Rna]]
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Current revision

Crystal structure of the glycine riboswitch bound to glycine

PDB ID 3owi

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