3pa0

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[[Image:3pa0.jpg|left|200px]]
 
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==Crystal Structure of Chiral Gamma-PNA with Complementary DNA Strand: Insight Into the Stability and Specificity of Recognition an Conformational Preorganization==
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The line below this paragraph, containing "STRUCTURE_3pa0", creates the "Structure Box" on the page.
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<StructureSection load='3pa0' size='340' side='right'caption='[[3pa0]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pa0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PA0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=40A:N-[(2S)-2-AMINOPROPYL]-N-[(6-AMINO-9H-PURIN-9-YL)ACETYL]GLYCINE'>40A</scene>, <scene name='pdbligand=40C:N-[(4-AMINO-2-OXOPYRIMIDIN-1(2H)-YL)ACETYL]-N-[(2S)-2-AMINOPROPYL]GLYCINE'>40C</scene>, <scene name='pdbligand=40G:N-[(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ACETYL]-N-[(2S)-2-AMINOPROPYL]GLYCINE'>40G</scene>, <scene name='pdbligand=40T:N-[(2S)-2-AMINOPROPYL]-N-[(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)ACETYL]GLYCINE'>40T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3pa0| PDB=3pa0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pa0 OCA], [https://pdbe.org/3pa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pa0 RCSB], [https://www.ebi.ac.uk/pdbsum/3pa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pa0 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the structure of a PNA-DNA duplex to 1.7 A resolution by multiple-wavelength anomalous diffraction phasing method on a zinc derivative. This structure represents the first high-resolution 3D view of a hybrid duplex containing a contiguous chiral PNA strand with complete gamma-backbone modification ("gammaPNA"). Unlike the achiral counterpart, which adopts a random-fold, this particular gammaPNA is already preorganized into a right-handed helix as a single strand. The new structure illustrates the unique characteristics of this modified PNA, possessing conformational flexibility while maintaining sufficient structural integrity to ultimately adopt the preferred P-helical conformation upon hybridization with DNA. The unusual structural adaptability found in the gammaPNA strand is crucial for enabling the accommodation of backbone modifications while constraining conformational states. In conjunction with NMR analysis characterizing the structures and substructures of the individual building blocks, these results provide unprecedented insights into how this new class of chiral gammaPNA is preorganized and stabilized, before and after hybridization with a cDNA strand. Such knowledge is crucial for the future design and development of PNA for applications in biology, biotechnology, and medicine.
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===Crystal Structure of Chiral Gamma-PNA with Complementary DNA Strand: Insight Into the Stability and Specificity of Recognition an Conformational Preorganization===
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Crystal structure of chiral gammaPNA with complementary DNA strand: insights into the stability and specificity of recognition and conformational preorganization.,Yeh JI, Shivachev B, Rapireddy S, Crawford MJ, Gil RR, Du S, Madrid M, Ly DH J Am Chem Soc. 2010 Aug 11;132(31):10717-27. PMID:20681704<ref>PMID:20681704</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20681704}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3pa0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20681704 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20681704}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3pa0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PA0 OCA].
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[[Category: Synthetic construct]]
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[[Category: Du S]]
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==Reference==
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[[Category: Shivachev B]]
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<ref group="xtra">PMID:20681704</ref><references group="xtra"/>
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[[Category: Yeh JI]]
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[[Category: Du, S.]]
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[[Category: Shivachev, B.]]
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[[Category: Yeh, J I.]]
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[[Category: Dna]]
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[[Category: Gamma-pna]]
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[[Category: Peptide nucleic acid-dna complex]]
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Current revision

Crystal Structure of Chiral Gamma-PNA with Complementary DNA Strand: Insight Into the Stability and Specificity of Recognition an Conformational Preorganization

PDB ID 3pa0

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