3pz8

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[[Image:3pz8.jpg|left|200px]]
 
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==Crystal structure of Dvl1-DIX(Y17D) mutant==
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The line below this paragraph, containing "STRUCTURE_3pz8", creates the "Structure Box" on the page.
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<StructureSection load='3pz8' size='340' side='right'caption='[[3pz8]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.873&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [https://pdbe.org/3pz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz8 ProSAT]</span></td></tr>
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{{STRUCTURE_3pz8| PDB=3pz8 | SCENE= }}
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</table>
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== Function ==
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===Molecular basis of WNT activation via the DIX-domain protein CCD1===
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[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3pz8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA].
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Dan, Q J.]]
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[[Category: Dan QJ]]
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[[Category: Liu, Y T.]]
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[[Category: Liu YT]]
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[[Category: Wu, J W.]]
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[[Category: Wu JW]]
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[[Category: Zhang, Y Y.]]
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[[Category: Zhang YY]]
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[[Category: Dix domain]]
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[[Category: Oligomerization]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of Dvl1-DIX(Y17D) mutant

PDB ID 3pz8

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OCA

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