2wb4

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[[Image:2wb4.png|left|200px]]
 
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==activated diguanylate cyclase PleD in complex with c-di-GMP==
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The line below this paragraph, containing "STRUCTURE_2wb4", creates the "Structure Box" on the page.
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<StructureSection load='2wb4' size='340' side='right'caption='[[2wb4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wb4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caulobacter_vibrioides_CB15 Caulobacter vibrioides CB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WB4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2wb4| PDB=2wb4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wb4 OCA], [https://pdbe.org/2wb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2wb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wb4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLED_CAUVN PLED_CAUVN] Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition.<ref>PMID:12622822</ref> Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger.<ref>PMID:15075296</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wb4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wb4 ConSurf].
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<div style="clear:both"></div>
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===ACTIVATED DIGUANYLATE CYCLASE PLED IN COMPLEX WITH C-DI-GMP===
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==See Also==
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*[[Diguanylate cyclase|Diguanylate cyclase]]
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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==About this Structure==
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== References ==
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[[2wb4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caulobacter_vibrioides Caulobacter vibrioides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WB4 OCA].
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<references/>
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[[Category: Caulobacter vibrioides]]
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__TOC__
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[[Category: Schirmer, T.]]
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</StructureSection>
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[[Category: Wassmann, P.]]
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[[Category: Caulobacter vibrioides CB15]]
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[[Category: Bef3-]]
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[[Category: Large Structures]]
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[[Category: C-di-gmp]]
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[[Category: Schirmer T]]
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[[Category: Cell cycle]]
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[[Category: Wassmann P]]
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[[Category: Differentiation]]
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[[Category: Diguanylate cyclase]]
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[[Category: Gtp-binding]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Response regulator]]
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[[Category: Transducer]]
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[[Category: Transferase]]
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[[Category: Two-component regulatory system]]
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Current revision

activated diguanylate cyclase PleD in complex with c-di-GMP

PDB ID 2wb4

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