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3pgd

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[[Image:3pgd.png|left|200px]]
 
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==Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation==
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The line below this paragraph, containing "STRUCTURE_3pgd", creates the "Structure Box" on the page.
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<StructureSection load='3pgd' size='340' side='right'caption='[[3pgd]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pgd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PGD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pgd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pgd OCA], [https://pdbe.org/3pgd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pgd RCSB], [https://www.ebi.ac.uk/pdbsum/3pgd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pgd ProSAT]</span></td></tr>
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{{STRUCTURE_3pgd| PDB=3pgd | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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T-cell recognition of peptides bound to MHC class II (MHCII) molecules is a central event in cell-mediated adaptive immunity. The current paradigm holds that prebound class II-associated invariant chain peptides (CLIP) and all subsequent antigens maintain a canonical orientation in the MHCII binding groove. Here we provide evidence for MHCII-bound CLIP inversion. NMR spectroscopy demonstrates that the interconversion from the canonical to the inverse alignment is a dynamic process, and X-ray crystallography shows that conserved MHC residues form a hydrogen bond network with the peptide backbone in both orientations. The natural catalyst HLA-DM accelerates peptide reorientation and the exchange of either canonically or inversely bound CLIP against antigenic peptide. Thus, noncanonical MHC-CLIP displays the hallmarks of a structurally and functionally intact antigen-presenting complex.
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===Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation===
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Bidirectional binding of invariant chain peptides to an MHC class II molecule.,Gunther S, Schlundt A, Sticht J, Roske Y, Heinemann U, Wiesmuller KH, Jung G, Falk K, Rotzschke O, Freund C Proc Natl Acad Sci U S A. 2010 Nov 29. PMID:21115828<ref>PMID:21115828</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3pgd" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21115828}}, adds the Publication Abstract to the page
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*[[MHC 3D structures|MHC 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21115828 is the PubMed ID number.
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*[[MHC II 3D structures|MHC II 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_21115828}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3pgd]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PGD OCA].
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==Reference==
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<ref group="xtra">PMID:21115828</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Falk, K.]]
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[[Category: Large Structures]]
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[[Category: Freund, C.]]
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[[Category: Falk K]]
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[[Category: Gunther, S.]]
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[[Category: Freund C]]
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[[Category: Heinemann, U.]]
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[[Category: Gunther S]]
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[[Category: Jung, G.]]
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[[Category: Heinemann U]]
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[[Category: Roske, Y.]]
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[[Category: Jung G]]
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[[Category: Rotzschke, O.]]
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[[Category: Roske Y]]
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[[Category: Schlundt, A.]]
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[[Category: Rotzschke O]]
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[[Category: Sticht, J.]]
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[[Category: Schlundt A]]
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[[Category: Wiesmuller, K H.]]
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[[Category: Sticht J]]
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[[Category: Wiesmuller K-H]]

Current revision

Crystal Structure of HLA-DR1 with CLIP106-120, canonical peptide orientation

PDB ID 3pgd

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