3q4t

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m (Protected "3q4t" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 3q4t is ON HOLD
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==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin==
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<StructureSection load='3q4t' size='340' side='right'caption='[[3q4t]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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Authors: Chaikuad, A., Alfano, I., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Krojer, T., Muniz, J.R.C., Raynor, J., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3q4t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q4T FirstGlance]. <br>
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Description: Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAK:6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE'>TAK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q4t OCA], [https://pdbe.org/3q4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q4t RCSB], [https://www.ebi.ac.uk/pdbsum/3q4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q4t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alfano I]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Bullock A]]
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[[Category: Chaikuad A]]
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[[Category: Cooper CDO]]
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[[Category: Edwards AM]]
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[[Category: Krojer T]]
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[[Category: Mahajan P]]
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[[Category: Muniz JRC]]
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[[Category: Raynor J]]
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[[Category: Sanvitale C]]
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[[Category: Vollmar M]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

PDB ID 3q4t

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